research collage

The Center provides the basic research foundation necessary for the applied goals of industry. Research projects, prioritized at the outset by the industry members, include pests of agricultural, medical and urban importance. Research areas include RNA interference, methods, genomics, novel target sites, and insect resistance.


Mechanisms of RNA interference:

Why does RNAi work so well in beetles, but not in other insects?

Establishment of midgut cell lines from select pest insects:

Development of methods and establishment of continuous cell lines from the midgut of selected pest insects to use for assessment of potential pest suppression agents

Integrating IPM into IRM theory for improved resistance management and pest suppression:

What are the prevalent factors influencing resistance to Bt crops, and what are the efficacies of various IPM strategies in delaying the evolution of resistance?

Understanding dispersal by western corn rootworm: effects of larval density on flight and effect of flight on female reproduction:

What are the effects of larval density on flight behavior, and how does flight behavior affect female reproductive output?


Mechanisms of transcytosis across the insect gut:

How are some proteins able to move from the gut into the hemocoel of an insect?

Characterization of digestive proteases and nucleases in stink bugs:

What enzymatic challenges will be faced by agents used for suppression of stink bug populations?

Toward increased efficacy of soybean cyst nematode management tools:

Development of innovative techniques for high-throughput, sensitive assessment of effects of nematode management compounds on the soybean cyst nematode life cycle

A toolkit to explore soybean cyst nematode genomic diversity:

Leveraging the recently assembled draft genome of the soybean cyst nematode to advance our understanding of the genetic diversity and pathology of soybean cyst nematodes

Enveloped porous nanoparticles for RNA delivery to insects:

Utilizing porous silica nanoparticles to deliver RNA and small proteins into insect cells, and investigating methods to facilitate the entry of nanoparticles into the cytoplasm via endocytosis


Beeman, A.Q., Njus, Z.L. Pandey, S., Tylka, G.L. 2016. Chip technologies for screening chemical and biological agents against plant-parasitic nematodes. Phytopathology 106(12):1563-1571.

Lomate, P.R., Bonning, B.C. 2016. Distinct properties of digestive proteases and nucleases in the gut, salivary gland and saliva of southern green stink bug, Nezara viridula. Sci Rep 6:27587.

Shukla JN, Kalsi M, Sethi A, Narva KE, Fishilevich E, Singh S, Mogilicherla K, Palli SR. 2016 Reduced stability and intracellular transport of dsRNA contribute to poor RNAi response in lepidopteran insects RNA Biol. 13: 656-69.

Yoon, J-S, Shukla, J.-N., Gong, Z.J., Mogilicherla, K., Palli, S.R. 2016. RNA interference in the Colorado potato beetle, Leptinotarsa decemlineata: Identification of key contributors Insect Biochem. Molec. Biol. 78:78-88.

Yoon, J-S, Gurusami, D, Palli, S.R. 2017. Accumulation of dsRNA in endosomes contributes to inefficient RNA interference in the fall armyworm, Spodoptera frugiperda Insect Biochem. Molec. Biol. 90:53-60.

Lomate, P.R. Bonning, B.C. 2018. Proteases and nucleases involved in the biphasic digestion process of the brown marmorated stink bug, Halyomorpha halys (Hemiptera: Pentatomidae). Arch Insect Biochem Physiol. e21459.